Abstract
Three herpes simplex virus mutants that contain drug resistance mutations in the DNA polymerase gene exhibited no significant reduction in replication in the ears of mice compared with the wild type after inoculation at that site but were attenuated for pathogenicity after intracerebral inoculation. Cataracts were common sequelae in mice that survived mutant infections.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Acyclovir / pharmacology
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Animals
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Cataract / etiology
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Cytarabine / pharmacology
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DNA-Directed DNA Polymerase / genetics*
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Drug Resistance
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Encephalitis / etiology
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Exodeoxyribonucleases / genetics*
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Female
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Herpes Simplex / etiology
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Herpes Simplex / microbiology
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Mice
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Mice, Inbred BALB C
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Simplexvirus / drug effects
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Simplexvirus / genetics
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Simplexvirus / pathogenicity*
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Viral Proteins*
Substances
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Viral Proteins
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Cytarabine
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DNA-Directed DNA Polymerase
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Exodeoxyribonucleases
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DNA polymerase, Simplexvirus
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Acyclovir