Heptose 1,7-Bisphosphate Directed TIFA Oligomerization: A Novel PAMP-Recognizing Signaling Platform in the Control of Bacterial Infections

Gastroenterology. 2018 Mar;154(4):778-783. doi: 10.1053/j.gastro.2018.01.009. Epub 2018 Jan 11.

Authors

Kumar Pachathundikandi¹, Steffen Backert¹

Affiliation

¹ Friedrich Alexander University Erlangen/Nuremberg, Erlangen, Germany.

PMID: 29337150
DOI: 10.1053/j.gastro.2018.01.009

No abstract available

Publication types

Editorial
Research Support, Non-U.S. Gov't

MeSH terms

Adaptor Proteins, Signal Transducing / metabolism*
Animals
Bacteria / immunology
Bacteria / metabolism*
Bacterial Infections / immunology
Bacterial Infections / metabolism*
Bacterial Infections / microbiology
Gastrointestinal Microbiome*
Gastrointestinal Tract / immunology
Gastrointestinal Tract / metabolism*
Gastrointestinal Tract / microbiology
Heptoses / immunology
Heptoses / metabolism*
Host-Pathogen Interactions
Humans
Inflammasomes / metabolism
NF-kappa B / metabolism
NLR Family, Pyrin Domain-Containing 3 Protein / metabolism
Neoplasms / immunology
Neoplasms / metabolism
Neoplasms / microbiology
Pathogen-Associated Molecular Pattern Molecules / metabolism*
Protein Kinases / metabolism
Protein Multimerization
Signal Transduction

Substances

Adaptor Proteins, Signal Transducing
Heptoses
Inflammasomes
NF-kappa B
NLR Family, Pyrin Domain-Containing 3 Protein
Pathogen-Associated Molecular Pattern Molecules
TIFA protein, human
Protein Kinases
ALPK1 protein, human