Protein phosphatase 1, regulatory subunit 15A (PPP1R15A), also known as growth arrest and DNA damage-inducible protein GADD34, plays a vital role in promoting cell death and the unfolded protein response (UPR). In order to explore whether the SNP (rs611251) of PPP1R15A gene has a role in different types of Epstein-Barr virus (EBV) - associated tumors, we detected the PPP1R15A gene rs611251 polymorphism in 195 cases of EBV positive tumors (93 lymphomas, 48 gastric carcinomas, 54 nasopharyngeal carcinomas), 208 cases of EBV-negative tumors (136 gastric carcinoma, 19 nasopharyngeal carcinomas, 53 lymphomas) and 113 peripheral blood samples from healthy individuals. Compared with normal controls, the wild type TT and allele T of rs611251 showed higher frequency in gastric carcinoma (GCs), nasopharyngeal carcinomas (NPCs) and lymphomas. However, there was no significant difference between EBV-associated gastric (EBVaGC) and EBVnGC, EBV-positive NPCs and EBV-negative NPCs, EBV-related lymphomas and EBV-negative lymphomas in rs611251 of PPP1R15A. In conclusion, the PPP1R15A rs611251 polymorphism was significantly related to three kinds of tumors. Nevertheless, EBV has no obvious effect on PPP1R15A rs611251 polymorphism of NPC, GC and lymphoma. What's more, the genotype TT and allele T could be risk factors for NPC, GC and lymphoma. Our study explores the relationship between PPP1R15A gene polymorphism (rs611251) and Epstein-Barr virus-associated tumors for the first time. PPP1R15A gene SNP (rs611251) have association with multiple tumor types, which may provide some new clues to the detection and treatment of tumors.
Keywords: PPP1R15A; GADD34; rs611251; gene polymorphism; Epstein-Barr virus; tumor..