Epistatic effects between pairs of the growth hormone secretagogue receptor 1a, growth hormone, growth hormone receptor, non-SMC condensin I complex, subunit G and stearoyl-CoA desaturase genes on carcass, price-related and fatty acid composition traits in Japanese Black cattle

Masanori Komatsu; Kagetomo Nishino; Yuki Fujimori; Yasutoshi Haga; Nagako Iwama; Aisaku Arakawa; Yoshito Aihara; Hisato Takeda; Hideaki Takahashi

doi:10.1111/asj.12947

Epistatic effects between pairs of the growth hormone secretagogue receptor 1a, growth hormone, growth hormone receptor, non-SMC condensin I complex, subunit G and stearoyl-CoA desaturase genes on carcass, price-related and fatty acid composition traits in Japanese Black cattle

Anim Sci J. 2018 Feb;89(2):273-288. doi: 10.1111/asj.12947. Epub 2017 Nov 20.

Authors

Masanori Komatsu^{1

2}, Kagetomo Nishino³, Yuki Fujimori^{3

4}, Yasutoshi Haga^{3

5}, Nagako Iwama^{3

6}, Aisaku Arakawa¹, Yoshito Aihara³, Hisato Takeda¹, Hideaki Takahashi¹

Affiliations

¹ Institute of Livestock and Grassland Science, National Agriculture and Food, Research Organization (NARO), Tsukuba, Ibaraki, Japan.
² Komatsu Laboratory of Computational Biology for Domestic Animals, Ryugasaki, Ibaraki, Japan.
³ Ibaraki Prefecture Livestock Research Centre, Hitachi-Ohmiya, Ibaraki, Japan.
⁴ Nagano Animal Industry Experiment Station, Shiojiri, Nagano, Japan.
⁵ Ibaraki Prefecture Agricultural College, Tsuchiura, Ibaraki, Japan.
⁶ Ibaraki Prefecture Ken-nan Livestock Office of Agriculture and Forestry, Tsuchiura, Ibaraki, Japan.

PMID: 29154485
DOI: 10.1111/asj.12947

Abstract

Growth hormone secretagogue receptor 1a (GHSR1a), growth hormone (GH), growth hormone receptor (GHR), non-SMC condensin I complex, subunit G (NCAPG) and stearoyl-CoA desaturase (SCD), are known to play important roles in growth and lipid metabolisms. Single and epistatic effects of the five genes on carcass, price-related and fatty acid (FA) composition traits were analyzed in a commercial Japanese Black cattle population of Ibaraki Prefecture. A total of 650 steers and 116 heifers for carcass and price-related traits, and 158 steers for FA composition traits were used in this study. Epistatic effects between pairs of the five genes were found in several traits. Alleles showing strain-specific differences in the five genes had significant single and epistatic effects in some traits. The data suggest that a TG-repeat polymorphism of the GHSR1a.5'UTR-(TG)_n locus plays a central role in gene-gene epistatic interaction of FA composition traits in the adipose tissue of Japanese Black cattle.

Keywords: NCAPG; GHSR1a/GH/GHR; Japanese Black cattle; carcass and fatty acids traits; epistasis.

MeSH terms

5' Untranslated Regions / genetics*
Adipose Tissue / metabolism*
Alleles
Animals
Cattle / genetics*
Cattle / metabolism*
Cell Cycle Proteins / genetics*
Commerce*
Epistasis, Genetic / genetics*
Fatty Acids / analysis*
Female
Growth Hormone / genetics*
Lipid Metabolism / genetics
Male
Meat / analysis*
Meat / economics*
Multifactorial Inheritance / genetics*
Receptors, Ghrelin / genetics*
Receptors, Somatotropin / genetics*
Stearoyl-CoA Desaturase / genetics*

Substances

5' Untranslated Regions
Cell Cycle Proteins
Fatty Acids
Receptors, Ghrelin
Receptors, Somatotropin
Growth Hormone
Stearoyl-CoA Desaturase