DAI-1 Receptor Expression in Placenta in Earlyand Late-Onset Preeclampsia

Bull Exp Biol Med. 2017 Nov;164(1):109-114. doi: 10.1007/s10517-017-3936-2. Epub 2017 Nov 11.

Abstract

DAI-1 receptor (DNA-dependent activator of IFN-regulatory factors; DLM-1/ZBP-1) is an innate immunity cytoplasmic receptor of the DNA-recognition receptor class of antiviral immunity. DAI-1 expression reflects the severity of the inflammatory response that plays the key role in the pathogenesis of pregnancy complications. We studied DAI-1 receptor expression in the placental villi in early- and late-onset preeclampsia. In case of early-onset preeclampsia DAI-1 staining intensity was lower (p=0.01), and in case of late preeclampsia - significantly higher (p<0.005) than in the reference groups at the corresponding gestational age. There was revealed a correlation between the decrease in DAI-1 receptor expression and the severity of disease progression.

Keywords: DAI-1; placenta; preeclampsia; syncytiotrophoblast.

MeSH terms

  • Adult
  • Age of Onset
  • Biomarkers / metabolism
  • Cell Membrane / metabolism
  • Cytoplasm / metabolism
  • DNA-Binding Proteins / genetics*
  • DNA-Binding Proteins / metabolism
  • Disease Progression
  • Female
  • Gene Expression
  • Humans
  • Placenta / metabolism*
  • Placenta / pathology
  • Pre-Eclampsia / metabolism*
  • Pre-Eclampsia / pathology
  • Pregnancy
  • RNA-Binding Proteins

Substances

  • Biomarkers
  • DNA-Binding Proteins
  • RNA-Binding Proteins
  • ZBP1 protein, human