HLA-DRB1 and HLA-DQB1 alleles in Chinese Han patients with Juvenile-Onset recurrent respiratory papillomatosis

Int J Pediatr Otorhinolaryngol. 2017 Nov:102:119-122. doi: 10.1016/j.ijporl.2017.04.017. Epub 2017 Apr 12.

Abstract

Juvenile-Onset recurrent respiratory papillomatosis (JORRP) is a rare benign neoplasm of the respiratory mucosa caused by human papilloma virus. Previous studies on the possible associations between HLA alleles and JORRP have shown various results in different ethnic groups. The present study aims to investigate the association between JORRP and HLA class II DRB1and DQB1 alleles in Chinese Han children. We found that the frequencies of HLA-DRB1*03:01 (pc = 0.0378, OR = 4.8) and HLA-DQB1*02:01 (pc = 0.021, OR = 4.8) alleles were significantly higher in patients with JORRP than in controls. In addition, HLA-DRB1*03:01 allele significantly correlated with aggressive JORRP (r = 0.467, p = 0.009). This was the first study on the HLA alleles in Chinese Han patients with JORRP. Future studies are required to further elucidate the correlation of HLA class II alleles and susceptibility to JORRP.

Keywords: Aggressive; Chinese Han population; HLA; Human papilloma virus (HPV); Juvenile-Onset recurrent respiratory papillomatosis (JORRP).

MeSH terms

  • Alleles
  • Asian People / genetics
  • Child
  • Child, Preschool
  • Female
  • Gene Frequency
  • Genotyping Techniques
  • HLA-DQ beta-Chains / genetics*
  • HLA-DRB1 Chains / genetics*
  • Humans
  • Infant
  • Male
  • Papillomaviridae
  • Papillomavirus Infections / genetics*
  • Respiratory Tract Infections / genetics*

Substances

  • HLA-DQ beta-Chains
  • HLA-DQB1 antigen
  • HLA-DRB1 Chains
  • HLA-DRB1*03:01 antigen

Supplementary concepts

  • Recurrent respiratory papillomatosis