The role of serum ADAMTS-1 and aggrecan on polycystic ovary syndrome in adolescents and younger-aged females

Arch Gynecol Obstet. 2018 Feb;297(2):487-493. doi: 10.1007/s00404-017-4578-3. Epub 2017 Oct 31.

Abstract

Purpose: The aim of this study was to analyze serum a disintegrin-like and metalloproteinase with thrombospondin-type motifs-1 (ADAMTS-1) and aggrecan levels in adolescents and younger-aged females with polycystic ovary syndrome (PCOS) compared with ovulatory controls to determine whether these are potential markers for the prediction of PCOS diagnosis. We also aimed to determine whether they could predict the development of clinical implications associated with PCOS.

Method: PCOS (n = 49) and ovulatory age-matched controls (n = 41) (mean age, 18.6 ± 2.5) were recruited. Anthropometric measurements were recorded and biochemical parameters were analyzed. Serum ADAMTS-1 and aggrecan levels were determined with enzyme-linked immunosorbent assay. The predictive effects of ADAMTS-1 and aggrecan on the diagnosis of PCOS and for the development of cardiovascular disease (CVD) risk and insulin resistance (IR) were evaluated. The correlation between investigated markers and anthropometric, biochemical, and hormonal parameters were also investigated.

Results: Mean serum ADAMTS-1 level was increased in adolescents and younger-aged females with PCOS compared to ovulatory controls. An elevated ADAMTS-1 level was positive predictive of the diagnosis of PCOS with the best cut-off value of 2.5 ng/ml (sensitivity 69% and specificity 78%). A positive predictive role of ADAMTS-1 on the development of CVD risk and IR was found among all patients. Serum ADAMTS-1 and aggrecan levels were significantly and positively correlated with each other.

Conclusion: Increased levels of ADAMTS-1 could be a potential marker for the etiopathogenesis of PCOS in adolescents and younger-aged females and predict the development of CVD risk and IR among all patients with the same age.

Keywords: ADAMTS-1; Adolescent; Aggrecan; PCOS; Younger-aged female.

MeSH terms

  • ADAMTS1 Protein / blood*
  • Adolescent
  • Aggrecans / blood*
  • Biomarkers / blood
  • Female
  • Humans
  • Insulin Resistance
  • Polycystic Ovary Syndrome / blood*
  • Predictive Value of Tests
  • Young Adult

Substances

  • Aggrecans
  • Biomarkers
  • ADAMTS1 Protein
  • ADAMTS1 protein, human