A human lymphoid-specific transcription factor that activates immunoglobulin genes is a homoeobox protein

Nature. 1988 Dec 8;336(6199):551-7. doi: 10.1038/336551a0.

Abstract

The human lymphoid-specific transcription factor OTF-2 contains a homoeodomain that is required for DNA binding and binds specifically to DNA elements that are recognized by Drosophila homoeodomain proteins, suggesting coevolutionary relationships between mammalian and invertebrate homoeodomain proteins and their DNA recognition elements.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Cloning, Molecular
  • DNA-Binding Proteins*
  • Gene Expression Regulation*
  • Genes, Homeobox*
  • Genes, Immunoglobulin*
  • Humans
  • Lymphocytes / immunology*
  • Molecular Sequence Data
  • Octamer Transcription Factor-2
  • Protein Conformation
  • RNA, Messenger / genetics
  • Sequence Homology, Nucleic Acid
  • Species Specificity
  • Transcription Factors / genetics
  • Transcription Factors / immunology*
  • Transcription, Genetic

Substances

  • DNA-Binding Proteins
  • Octamer Transcription Factor-2
  • POU2F2 protein, human
  • RNA, Messenger
  • Transcription Factors