A cloned octamer transcription factor stimulates transcription from lymphoid-specific promoters in non-B cells

M M Müller; S Ruppert; W Schaffner; P Matthias

doi:10.1038/336544a0

A cloned octamer transcription factor stimulates transcription from lymphoid-specific promoters in non-B cells

Nature. 1988 Dec 8;336(6199):544-51. doi: 10.1038/336544a0.

Authors

M M Müller¹, S Ruppert, W Schaffner, P Matthias

Affiliation

¹ Institut für Molekularbiologie II der Universität Zürich, Switzerland.

PMID: 2904653
DOI: 10.1038/336544a0

Abstract

The complementary DNA coding for a lymphocyte-specific transcription factor binding to the DNA 'octamer' sequence TNATTTGCAT has been cloned. The nucleotide sequence shows homology to the homoeobox domain. Expression of this cDNA in HeLa cells is sufficient for a strong transcriptional activation of B-cell-specific promoters.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Sequence
B-Lymphocytes / metabolism
Base Sequence
Cell Line
Cloning, Molecular*
Genes
Genes, Homeobox
Humans
Lymphocytes / metabolism*
Molecular Sequence Data
Promoter Regions, Genetic*
Transcription Factors / genetics*
Transcription Factors / physiology

Substances

Transcription Factors