The Recent Crystal Structure of Human Tyrosinase Related Protein 1 (HsTYRP1) Solves an Old Problem and Poses a New One

Angew Chem Int Ed Engl. 2017 Nov 13;56(46):14352-14354. doi: 10.1002/anie.201708214. Epub 2017 Oct 9.

Abstract

Show your metal: l-Tyrosine is converted into the protective antioxidative polymer melanin in a sequence of reactions. In humans, the catalytic pathway starts with the tyrosinase HsTYR and two tyrosinase-related proteins HsTYRP1 and HsTYRP2. All three enzymes have the same active site but the latter two contain two zinc ions instead of copper ions.

Keywords: TYRP1; enzymes; melanosomes; protein structures; tyrosinase.

MeSH terms

  • Antioxidants / chemistry
  • Catalysis
  • Catalytic Domain
  • Copper / chemistry
  • Crystallography, X-Ray
  • Humans
  • Melanins / chemistry
  • Membrane Glycoproteins / chemistry*
  • Membrane Glycoproteins / physiology
  • Oxidoreductases / chemistry*
  • Oxidoreductases / physiology
  • Protein Conformation
  • Tyrosine / chemistry
  • Zinc / chemistry

Substances

  • Antioxidants
  • Melanins
  • Membrane Glycoproteins
  • Tyrosine
  • Copper
  • Oxidoreductases
  • TYRP1 protein, human
  • Zinc