Abstract
Syndecan 2 (SDC2) belongs to a four-member family of evolutionary conserved small type I transmembrane proteoglycans consisting of a protein core to which glycosaminoglycan chains are covalently attached. SDC2 is a cell surface heparan sulfate proteoglycan, which is increasingly drawing attention for its distinct characteristics and its participation in numerous cell functions, including those related to carcinogenesis. Increasing evidence suggests that the role of SDC2 in cancer pathogenesis is dependent on cancer tissue origin rendering its use as a biomarker/therapeutic target feasible. This mini review discusses the mechanisms, through which SDC2, in a distinct manner, modulates complex signalling networks to affect cancer progression. © 2017 IUBMB Life, 69(11):824-833, 2017.
Keywords:
cancer biology; glycobiology; proteoglycans; syndecan.
© 2017 International Union of Biochemistry and Molecular Biology.
MeSH terms
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Actin Cytoskeleton / metabolism
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Actin Cytoskeleton / pathology
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Breast Neoplasms / genetics*
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Breast Neoplasms / metabolism
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Breast Neoplasms / pathology
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Cell Line, Tumor
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Cell Membrane / metabolism
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Cell Membrane / pathology
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Colonic Neoplasms / genetics*
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Colonic Neoplasms / metabolism
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Colonic Neoplasms / pathology
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Disease Progression
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Female
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Fibrosarcoma / genetics*
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Fibrosarcoma / metabolism
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Fibrosarcoma / pathology
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Gene Expression Regulation, Neoplastic*
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Humans
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Intercellular Signaling Peptides and Proteins / genetics
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Intercellular Signaling Peptides and Proteins / metabolism
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Organ Specificity
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Osteosarcoma / genetics*
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Osteosarcoma / metabolism
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Osteosarcoma / pathology
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Pancreatic Neoplasms / genetics*
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Pancreatic Neoplasms / metabolism
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Pancreatic Neoplasms / pathology
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Protein Domains
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Signal Transduction
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Syndecan-2 / genetics*
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Syndecan-2 / metabolism
Substances
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Intercellular Signaling Peptides and Proteins
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SDC2 protein, human
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Syndecan-2