Abstract
Bovine tuberculosis (bTB) is a zoonotic disease caused by Mycobacterium bovis that is responsible for significant economic losses worldwide. In spite of its relevance, the limited knowledge about the host immune responses that provide effective protection against the disease has long hampered the development of an effective vaccine. The identification of host proteins with an expression that correlates with protection against bTB would contribute to the understanding of the cattle defence mechanisms against M. bovis infection. In this study, we found that ERAP1 and PDE8A were downregulated in vaccinated cattle that were protected from experimental M. bovis challenge. Remarkably, both genes encode proteins that have been negatively associated with immune protection against bTB.
Keywords:
Cattle; Immune response; Mycobacterium bovis; Transcriptomics.
© 2017 S. Karger AG, Basel.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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3',5'-Cyclic-AMP Phosphodiesterases / genetics
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3',5'-Cyclic-AMP Phosphodiesterases / metabolism
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Aminopeptidases / genetics
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Aminopeptidases / metabolism
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Animals
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Cattle / genetics*
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Cattle / immunology*
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Down-Regulation*
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Gene Expression Regulation / genetics*
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Gene Expression Regulation / immunology*
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Host-Pathogen Interactions / genetics
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Host-Pathogen Interactions / immunology
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Minor Histocompatibility Antigens / genetics
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Minor Histocompatibility Antigens / metabolism
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Mycobacterium bovis / immunology*
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Mycobacterium bovis / pathogenicity
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RNA, Messenger / biosynthesis
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Tuberculosis Vaccines / immunology
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Tuberculosis, Bovine / immunology
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Tuberculosis, Bovine / prevention & control*
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Vaccination
Substances
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Minor Histocompatibility Antigens
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RNA, Messenger
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Tuberculosis Vaccines
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3',5'-Cyclic-AMP Phosphodiesterases
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Aminopeptidases