New tricks for an old dog: Brf2-dependent RNA Polymerase III transcription in oxidative stress and cancer

Transcription. 2018;9(1):61-66. doi: 10.1080/21541264.2017.1335269. Epub 2017 Aug 30.

Abstract

Here, we discuss the role of Brf2, an RNA Polymerase III core transcription factor, as a master switch of the oxidative stress response. We highlight the interplay of Brf2 with the Nrf2/Keap1 pathway, as well as the role of Brf2 in cancer and other possible regulations.

Keywords: Brf2; Nrf2; RNA polymerase III; redox stress; transcription.

Publication types

  • Review

MeSH terms

  • Humans
  • Neoplasms / genetics*
  • Neoplasms / metabolism
  • Oxidative Stress / genetics*
  • RNA Polymerase III / metabolism*
  • Transcription Factor TFIIIB / metabolism*
  • Transcription, Genetic*

Substances

  • BRF2 protein, human
  • Transcription Factor TFIIIB
  • RNA Polymerase III