Interplay between hepatitis C virus and ARF4

Na Zhang; Youyang Ke; Leiliang Zhang

doi:10.1007/s12250-017-4000-0

Interplay between hepatitis C virus and ARF4

Virol Sin. 2017 Dec;32(6):533-536. doi: 10.1007/s12250-017-4000-0.

Authors

Na Zhang¹, Youyang Ke², Leiliang Zhang³

Affiliations

¹ MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100176, China.
² Department of Emergency, 171st Hospital of PLA, Jiujiang, 332000, China. keyouyang001@163.com.
³ MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100176, China. armzhang@hotmail.com.

Abstract

In summary, we show here that HCV infection is associated with an upregulation of ARF4, which promotes HCV replication. Upon HCV infection, CREB3 was redistributed to nucleus and activated ARF4 transcription. Our studies demonstrate a host factor ARF4 upregulated in HCV replication, which may provide new therapeutic targets for antiviral therapy.

Publication types

Letter

MeSH terms

ADP-Ribosylation Factors / biosynthesis*
Cyclic AMP Response Element-Binding Protein / metabolism*
Gene Expression Profiling
Gene Expression Regulation*
Hepacivirus / physiology*
Host-Pathogen Interactions*
RNA, Messenger / biosynthesis
Virus Replication*

Substances

CREB3 protein, human
Cyclic AMP Response Element-Binding Protein
RNA, Messenger
ADP-Ribosylation Factors
ARF4 protein, human