Phosphatases and solid tumors: focus on glioblastoma initiation, progression and recurrences

Biochem J. 2017 Aug 11;474(17):2903-2924. doi: 10.1042/BCJ20170112.

Abstract

Phosphatases and cancer have been related for many years now, as these enzymes regulate key cellular functions, including cell survival, migration, differentiation and proliferation. Dysfunctions or mutations affecting these enzymes have been demonstrated to be key factors for oncogenesis. The aim of this review is to shed light on the role of four different phosphatases (PTEN, PP2A, CDC25 and DUSP1) in five different solid tumors (breast cancer, lung cancer, pancreatic cancer, prostate cancer and ovarian cancer), in order to better understand the most frequent and aggressive primary cancer of the central nervous system, glioblastoma.

Keywords: cancer stem cells; glioma; protein phosphatases; treatments.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Transformation, Neoplastic / genetics
  • Cell Transformation, Neoplastic / metabolism*
  • Central Nervous System Neoplasms / enzymology*
  • Central Nervous System Neoplasms / genetics
  • Female
  • Glioblastoma / enzymology*
  • Glioblastoma / genetics
  • Humans
  • Male
  • Neoplasm Proteins / genetics
  • Neoplasm Proteins / metabolism*
  • Phosphoprotein Phosphatases / genetics
  • Phosphoprotein Phosphatases / metabolism*

Substances

  • Neoplasm Proteins
  • Phosphoprotein Phosphatases