Abstract
Because IL-13 induces expression of the anti-apoptotic Bcl-2 and the pro-apoptotic Bik, blocking Bcl-2 causes a Bik-dependent death of hyperplastic mucous cells. Therefore, the Bcl-2-inhibitor, ABT-263, may be highly efficient in reducing mucous hypersecretion.
Publication types
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Letter
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Adaptor Proteins, Signal Transducing / physiology*
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Allergens / immunology
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Aniline Compounds / pharmacology
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Aniline Compounds / therapeutic use
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Animals
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Apoptosis Regulatory Proteins
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Asthma / drug therapy
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Asthma / immunology
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Cells, Cultured
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Epithelial Cells / pathology
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Epithelial Cells / physiology*
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Humans
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Hyperplasia
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Interleukin-13 / physiology*
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Mice, Inbred C57BL
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Mice, Knockout
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Mitochondrial Proteins / physiology*
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Mucin 5AC / physiology
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Ovalbumin / immunology
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Proto-Oncogene Proteins c-bcl-2 / physiology*
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Sulfonamides / pharmacology
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Sulfonamides / therapeutic use
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Trachea / cytology
Substances
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Adaptor Proteins, Signal Transducing
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Allergens
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Aniline Compounds
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Apoptosis Regulatory Proteins
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Bik protein, mouse
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Interleukin-13
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Mitochondrial Proteins
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Mucin 5AC
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Proto-Oncogene Proteins c-bcl-2
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Sulfonamides
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Ovalbumin
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navitoclax