Nogo proteins play an important role in the apoptosis of cells, especially in tumor cells. The present study was conducted to evaluate whether the TATC (rs71682980) and CAA (rs34917480) insertion/deletion polymorphisms of RTN4 3'-UTR are associated with clear cell renal cell carcinoma (ccRCC). These two polymorphisms were genotyped in 308 ccRCC patients and 466 healthy controls by polymerase chain reaction polyacrylamide gel electrophoresis (PCR-PAGE). Significantly reduced ccRCC risk was observed to be associated with the TATCins/ins genotype carriers (Versus TATCdel/del: adjusted OR 0.53, 95% CI 0.32-0.87, P = 0.022; Versus TATCdel/del-del/ins: adjusted OR 0.57, 95% CI 0.36-0.92, P = 0.017). After performing stratification analysis, the frequency of TATCins/ins genotype was observed to be significantly higher in patients with N0 compared the patients with N1 (P = 0.003). The present study provide evidence for the first time that the TATC insertion/deletion polymorphism in RTN4 3'-UTR may contributes to ccRCC risk in Chinese Han population.
Keywords: Clear cell renal cell carcinoma; Genetic susceptibility; Nogo proteins; Polymorphism; RTN4.