Cytoplasmic E2f4 forms organizing centres for initiation of centriole amplification during multiciliogenesis

Nat Commun. 2017 Jul 4:8:15857. doi: 10.1038/ncomms15857.

Abstract

Abnormal development of multiciliated cells is a hallmark of a variety of human conditions associated with chronic airway diseases, hydrocephalus and infertility. Multiciliogenesis requires both activation of a specialized transcriptional program and assembly of cytoplasmic structures for large-scale centriole amplification that generates basal bodies. It remains unclear, however, what mechanism initiates formation of these multiprotein complexes in epithelial progenitors. Here we show that this is triggered by nucleocytoplasmic translocation of the transcription factor E2f4. After inducing a transcriptional program of centriole biogenesis, E2f4 forms apical cytoplasmic organizing centres for assembly and nucleation of deuterosomes. Using genetically altered mice and E2F4 mutant proteins we demonstrate that centriole amplification is crucially dependent on these organizing centres and that, without cytoplasmic E2f4, deuterosomes are not assembled, halting multiciliogenesis. Thus, E2f4 integrates nuclear and previously unsuspected cytoplasmic events of centriole amplification, providing new perspectives for the understanding of normal ciliogenesis, ciliopathies and cancer.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Active Transport, Cell Nucleus
  • Animals
  • Autoantigens / metabolism
  • Basal Bodies / metabolism
  • Cell Cycle Proteins / metabolism
  • Centrioles / metabolism*
  • Cilia / metabolism*
  • Cytoplasm / metabolism*
  • Cytoplasmic Granules / metabolism
  • E2F4 Transcription Factor / metabolism*
  • Female
  • Humans
  • Male
  • Mice, Inbred C57BL
  • Transcription, Genetic

Substances

  • Autoantigens
  • Cell Cycle Proteins
  • E2F4 Transcription Factor
  • E2F4 protein, human
  • E2f4 protein, mouse
  • PCM1 protein, human
  • Pcm1 protein, mouse