MiR-204/ZEB2 axis functions as key mediator for MALAT1-induced epithelial-mesenchymal transition in breast cancer

Tumour Biol. 2017 Jul;39(7):1010428317690998. doi: 10.1177/1010428317690998.

Abstract

Long non-coding RNAs recently were identified as key mediators of cancer metastasis. This study provided evidence that long non-coding RNA MALAT1 was up-regulated in breast cancer tissues and cell lines. MALAT1 promoted cancer cell invasion through inducing epithelial-mesenchymal transition. Interestingly, we revealed there was a reciprocal repression between MALAT1 and miR-204. ZEB2 was identified as a downstream target of miR-204 and MALAT1 exerted its function mainly through the miR-204/ZEB2 axis. Our findings suggested that MALAT1 may serve as a new diagnostic biomarker and therapy target for breast cancer.

Keywords: MALAT1; ZEB2; epithelial–mesenchymal transition; miR-204.

MeSH terms

  • Adult
  • Aged
  • Animals
  • Biomarkers, Tumor / genetics*
  • Breast Neoplasms / genetics*
  • Breast Neoplasms / pathology
  • Cell Line, Tumor
  • Epithelial-Mesenchymal Transition / genetics
  • Female
  • Homeodomain Proteins / genetics*
  • Humans
  • Mice
  • MicroRNAs / genetics*
  • Middle Aged
  • RNA, Long Noncoding / genetics*
  • Repressor Proteins / genetics*
  • Signal Transduction
  • Xenograft Model Antitumor Assays
  • Zinc Finger E-box Binding Homeobox 2

Substances

  • Biomarkers, Tumor
  • Homeodomain Proteins
  • MALAT1 long non-coding RNA, human
  • MIRN204 microRNA, human
  • MicroRNAs
  • RNA, Long Noncoding
  • Repressor Proteins
  • ZEB2 protein, human
  • Zinc Finger E-box Binding Homeobox 2