Regulation of cathepsin D activity by the FTLD protein progranulin

Acta Neuropathol. 2017 Jul;134(1):151-153. doi: 10.1007/s00401-017-1719-5. Epub 2017 May 10.
No abstract available

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Brain / metabolism
  • Cathepsin D / metabolism*
  • Cell Line, Tumor
  • Frontotemporal Lobar Degeneration / metabolism
  • Granulins
  • HEK293 Cells
  • Humans
  • Intercellular Signaling Peptides and Proteins / deficiency*
  • Intercellular Signaling Peptides and Proteins / genetics
  • Intercellular Signaling Peptides and Proteins / metabolism*
  • Liver / metabolism
  • Lysosomes / metabolism
  • Mice
  • Mice, Knockout
  • Progranulins
  • Saposins / deficiency
  • Saposins / genetics
  • Spleen / metabolism

Substances

  • GRN protein, human
  • Granulins
  • Grn protein, mouse
  • Intercellular Signaling Peptides and Proteins
  • Progranulins
  • Psap protein, mouse
  • Saposins
  • CTSD protein, human
  • Cathepsin D
  • Ctsd protein, mouse