Positive association between ALDH2 rs671 polymorphism and essential hypertension: A case-control study and meta-analysis

Yinyin Wu; Juntao Ni; Xiao Cai; Fuzhi Lian; Haiyan Ma; Liangwen Xu; Lei Yang

doi:10.1371/journal.pone.0177023

Positive association between ALDH2 rs671 polymorphism and essential hypertension: A case-control study and meta-analysis

PLoS One. 2017 May 4;12(5):e0177023. doi: 10.1371/journal.pone.0177023. eCollection 2017.

Authors

Yinyin Wu¹, Juntao Ni¹, Xiao Cai¹, Fuzhi Lian¹, Haiyan Ma¹, Liangwen Xu¹, Lei Yang¹

Affiliation

¹ School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang, China.

Abstract

Background and objective: Several studies have been conducted to examine the association between aldehyde dehydrogenase 2 family (ALDH2) rs671 polymorphism and essential hypertension (EH). However, the results remain inconsistent. This study aimed to clarify the association between ALDH2 rs671 polymorphism and EH susceptibility.

Methods: One thousand and ninety-four cases and 1236 controls who were ethnic Han Chinese were collected for this population-based case-control study. A meta-analysis was performed to calculate the pooled odds ratio and 95% confidence interval, using allele contrast, dominant, recessive, and co-dominant models using fixed or random-effect models.

Results: Significant differences were observed between EH cases and controls at the level of both genotype (χ2 = 6.656, P<0.05) and alleles (χ2 = 6.314, P<0.05). An additional meta-analysis using 4204 cases and 5435 controls established that rs671 was significantly associated with EH (P<0.00001).

Conclusion: The results of our case-control study and meta-analysis showed that there is a significant association between ALDH2 rs671 polymorphism and EH susceptibility. In addition, the results of the breakdown analysis by gender suggest a male-specific association between the ALDH2 rs671 polymorphism and EH.

Publication types

Meta-Analysis

MeSH terms

Aldehyde Dehydrogenase, Mitochondrial / genetics*
Case-Control Studies
China
Female
Genetic Predisposition to Disease*
Humans
Hypertension / genetics*
Male
Polymorphism, Single Nucleotide*

Substances

ALDH2 protein, human
Aldehyde Dehydrogenase, Mitochondrial

Grants and funding

This work was supported by the Program for Zhejiang Leading Team of Science and Technology Innovation (No. 2011R50021) and the Zhejiang Provincial Natural Science Foundation of China (No. LQ16H260002). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.