Microvascular injury and the kidney in hypertension

Hipertens Riesgo Vasc. 2018 Jan-Mar;35(1):24-29. doi: 10.1016/j.hipert.2017.03.002. Epub 2017 Apr 18.

Abstract

Renal macrocirculation participates in the development of arterial hypertension. The elevation in systemic blood pressure (BP) can damage the kidney starting in the microcirculation. Established arterial hypertension impinge upon the large arteries and stiffness develops. As a consequence central BP raises and BP pulsatility appear and contribute to further damage renal microcirculation by direct transmission of the elevated BP.

Keywords: Arterial hypertension; Chronic kidney disease; Enfermedad renal crónica; Hemodinámica renal; Hipertensión; Hipertensión arterial; Hypertension; Microcirculación renal; Renal; Renal hemodynamics; Renal microcirculation.

Publication types

  • Review

MeSH terms

  • Animals
  • Antihypertensive Agents / therapeutic use
  • Blood Pressure / physiology
  • Cardiomegaly / etiology
  • Humans
  • Hypertension / drug therapy
  • Hypertension / pathology*
  • Hypertension / physiopathology
  • Kidney / blood supply
  • Kidney / pathology*
  • Kidney / physiopathology
  • Kidney Diseases / etiology
  • Kidney Diseases / physiopathology
  • Microcirculation
  • Models, Biological
  • Nephrons / abnormalities
  • Pulsatile Flow
  • Rats
  • Rats, Inbred SHR

Substances

  • Antihypertensive Agents