CXCR6 gene characterization in two ethnically distinct South African populations and association with viraemic disease control in HIV-1-infected black South African individuals

Clin Immunol. 2017 Jul:180:69-79. doi: 10.1016/j.clim.2017.04.006. Epub 2017 Apr 18.

Abstract

CXCR6 genetic variation was described for HIV-1-uninfected black (n=41) and Caucasian (n=40) South Africans. We also investigated the CXCR6 rs2234358 and rs2234355 single nucleotide polymorphisms in HIV-1 disease control in 124 HIV-1-infected drug-naïve black individuals [elite controllers (n=11), viraemic controllers (VCs, n=30), high viral load long-term nonprogressors (HVL LTNPs, n=11) and progressors (n=72)] compared to healthy controls (HCs; n=232). The rs2234358-T allele was underrepresented in VCs (40.0%) compared to HCs (59%, P=0.006), HVL LTNPs (72.7%, P=0.012) and progressors (59%, P=0.014). The rs2234358-TT genotype was underrepresented in VCs (7%) compared to progressors (32%; OR=6.57, P=0.006) and HCs (35%; OR=7.18, P=0.001, Pbonferroni=0.034). The rs2234355-GA genotype was overrepresented in VCs (80%) compared to HCs (50.4%; OR=0.25, P=0.003) and progressors (29.17%; OR=0.10, P=3.8×10-5, Pbonferroni=0.001). The combination of rs2234355-GA in the absence of rs2234358-TT was overrepresented in VCs (80%) compared to HCs (32.6%, OR=0.12, P=1×10-6, Pbonferroni=3.4×10-5) and to progressors (16.7%; OR=0.05, P<1×10-8, Pbonferroni<1×10-7).

Keywords: CXCR6; HIV-1 control; Haplotypes; Single nucleotide polymorphisms.

MeSH terms

  • Adult
  • Aged
  • Black People / genetics*
  • Female
  • HIV Infections / genetics*
  • HIV Infections / virology
  • HIV-1
  • Haplotypes
  • Humans
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide
  • Receptors, CXCR6
  • Receptors, Chemokine / genetics*
  • Receptors, Virus / genetics*
  • South Africa
  • Viral Load
  • Viremia / genetics*
  • White People / genetics*
  • Young Adult

Substances

  • CXCR6 protein, human
  • Receptors, CXCR6
  • Receptors, Chemokine
  • Receptors, Virus