Abstract
S100A6 protein belongs to the A group of the S100 protein family of Ca2+-binding proteins. It is expressed in a limited number of cell types in adult normal tissues and in several tumor cell types. As an intracellular protein, S100A6 has been implicated in the regulation of several cellular functions, such as proliferation, apoptosis, the cytoskeleton dynamics, and the cellular response to different stress factors. S100A6 can be secreted/released by certain cell types which points to extracellular effects of the protein. RAGE (receptor for advanced glycation endproducts) and integrin β1 transduce some extracellular S100A6's effects. Dosage of serum S100A6 might aid in diagnosis in oncology.
Keywords:
Cancer; Cytoskeleton; Invasion; Migration/motility; Proliferation; Receptor; S100A6 protein.
Publication types
-
Review
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Apoptosis
-
Cell Cycle Proteins / blood
-
Cell Cycle Proteins / genetics
-
Cell Cycle Proteins / metabolism*
-
Cell Movement
-
Cell Proliferation*
-
Cytoskeleton / genetics
-
Cytoskeleton / metabolism
-
Gene Expression Regulation
-
Humans
-
Integrin beta1 / metabolism
-
Neoplasms / blood
-
Neoplasms / genetics
-
Neoplasms / metabolism*
-
Neurodegenerative Diseases / genetics
-
Neurodegenerative Diseases / metabolism
-
Receptor for Advanced Glycation End Products / metabolism
-
S100 Calcium Binding Protein A6
-
S100 Proteins / blood
-
S100 Proteins / genetics
-
S100 Proteins / metabolism*
-
Signal Transduction
-
Stem Cells / metabolism
Substances
-
Cell Cycle Proteins
-
Integrin beta1
-
Receptor for Advanced Glycation End Products
-
S100 Calcium Binding Protein A6
-
S100 Proteins
-
S100A6 protein, human