Pharmacotherapeutic Management of Pancreatic Ductal Adenocarcinoma: Current and Emerging Concepts

Dietrich A Ruess; Kivanc Görgülü; Sonja M Wörmann; Hana Algül

doi:10.1007/s40266-017-0453-y

Pharmacotherapeutic Management of Pancreatic Ductal Adenocarcinoma: Current and Emerging Concepts

Drugs Aging. 2017 May;34(5):331-357. doi: 10.1007/s40266-017-0453-y.

Authors

Dietrich A Ruess¹, Kivanc Görgülü², Sonja M Wörmann², Hana Algül³

Affiliations

¹ Internal Medicine II, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, 81675, Munich, Germany. dietrich.ruess@uniklinik-freiburg.de.
² Internal Medicine II, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, 81675, Munich, Germany.
³ Internal Medicine II, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, 81675, Munich, Germany. hana.alguel@mri.tum.de.

PMID: 28349415
DOI: 10.1007/s40266-017-0453-y

Abstract

Pancreatic ductal adenocarcinoma is a devastating malignancy, which is the result of late diagnosis, aggressive disease, and a lack of effective treatment options. Thus, pancreatic ductal adenocarcinoma is projected to become the second leading cause of cancer-related death by 2030. This review summarizes recent developments of oncological therapy in the palliative setting of metastatic pancreatic ductal adenocarcinoma. It further compiles novel targets and therapeutic approaches as well as promising treatment combinations, which are presently in preclinical evaluation, covering several aspects of the hallmarks of cancer. Finally, challenges to the implementation of an individualized therapy approach in the context of precision medicine are discussed.

Publication types

Review

MeSH terms

Adenocarcinoma / drug therapy*
Adenocarcinoma / genetics
Adenocarcinoma / mortality
Adenocarcinoma / pathology
Antineoplastic Combined Chemotherapy Protocols / administration & dosage
Antineoplastic Combined Chemotherapy Protocols / adverse effects
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
Carcinoma, Pancreatic Ductal / drug therapy*
Carcinoma, Pancreatic Ductal / genetics
Carcinoma, Pancreatic Ductal / mortality
Carcinoma, Pancreatic Ductal / pathology
Clinical Trials as Topic
Humans
Medication Therapy Management
Molecular Targeted Therapy
Palliative Care
Pancreatic Neoplasms / drug therapy*
Pancreatic Neoplasms / genetics
Pancreatic Neoplasms / mortality
Pancreatic Neoplasms / pathology
Precision Medicine
Survival Analysis
Treatment Outcome