RIC3 variants are not associated with Parkinson's disease in French-Canadians and French

Jay P Ross; Nicolas Dupré; Yves Dauvilliers; Stephanie Strong; Alexandre Dionne-Laporte; Patrick A Dion; Guy A Rouleau; Ziv Gan-Or

doi:10.1016/j.neurobiolaging.2017.01.005

RIC3 variants are not associated with Parkinson's disease in French-Canadians and French

Neurobiol Aging. 2017 May:53:194.e9-194.e11. doi: 10.1016/j.neurobiolaging.2017.01.005. Epub 2017 Jan 11.

Authors

Jay P Ross¹, Nicolas Dupré², Yves Dauvilliers³, Stephanie Strong⁴, Alexandre Dionne-Laporte⁴, Patrick A Dion⁴, Guy A Rouleau⁵, Ziv Gan-Or⁶

Affiliations

¹ Department of Human Genetics, McGill University, Montréal, Québec, Canada; Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montréal, Québec, Canada.
² Division of Neurology, CHU de Québec, Faculty of Medicine, Laval University, Quebec City, Québec, Canada.
³ Sleep Unit, National Reference Network for Narcolepsy, Department of Neurology, Hôpital-Gui-de Chauliac, CHU Montpellier, INSERM U1061, Montpellier, France.
⁴ Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montréal, Québec, Canada; Department of Neurology and Neurosurgery, McGill University, Montréal, Québec, Canada.
⁵ Department of Human Genetics, McGill University, Montréal, Québec, Canada; Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montréal, Québec, Canada; Department of Neurology and Neurosurgery, McGill University, Montréal, Québec, Canada.
⁶ Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montréal, Québec, Canada; Department of Neurology and Neurosurgery, McGill University, Montréal, Québec, Canada. Electronic address: ziv.gan-or@mail.mcgill.ca.

PMID: 28153381
DOI: 10.1016/j.neurobiolaging.2017.01.005

Abstract

Variants in the RIC3 gene have recently been suggested as a novel cause of Parkinson's disease (PD). Herein, the entire RIC3 gene was sequenced in a French-Canadian and French sample series of 535 PD patients and 527 unaffected controls. The effect of single variants and the combined effect of variants were calculated. Sequence Kernel association tests (SKAT, SKAT-O) were done on the entire gene level, and on the different domains and exons of RIC3. A total of 28 common and rare variants were identified in patients and controls. No significant association was found between any variant and haplotype in RIC3 and PD, and there was no over-representation of RIC3 variants at the entire gene, domain, or exon levels in patients versus controls. Our results do not support a role for RIC3 mutations as a common cause of PD in the French-Canadian and French populations.

Keywords: Genetics; Parkinson's disease; RIC3.

MeSH terms

Adult
Canada
Female
France
Genetic Association Studies*
Genetic Predisposition to Disease / genetics*
Genetic Variation / genetics*
Humans
Intracellular Signaling Peptides and Proteins / genetics*
Male
Middle Aged
Mutation / genetics*
Parkinson Disease / genetics*

Substances

Intracellular Signaling Peptides and Proteins
RIC3 protein, human