Platelet CD34 expression and α/δ-granule abnormalities in GFI1B- and RUNX1-related familial bleeding disorders

Blood. 2017 Mar 23;129(12):1733-1736. doi: 10.1182/blood-2016-11-749366. Epub 2017 Jan 17.

Affiliations

¹ Department of Laboratory Medicine, Laboratory of Hematology, Radboud Institute for Molecular Life Sciences.
² Department of Pathology.
³ Department of Hematology, and.
⁴ Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands; and.
⁵ Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands.

PMID: 28096094
DOI: 10.1182/blood-2016-11-749366

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Antigens, CD34 / biosynthesis*
Antigens, CD34 / genetics
Blood Coagulation Disorders, Inherited / genetics
Blood Coagulation Disorders, Inherited / metabolism*
Blood Coagulation Disorders, Inherited / pathology
Blood Platelets / metabolism*
Blood Platelets / pathology
Core Binding Factor Alpha 2 Subunit / genetics
Core Binding Factor Alpha 2 Subunit / metabolism*
Cytoplasmic Granules / genetics
Cytoplasmic Granules / metabolism*
Cytoplasmic Granules / pathology
Female
Gene Expression Regulation*
Humans
Male
Mutation
Proto-Oncogene Proteins / genetics
Proto-Oncogene Proteins / metabolism*
Repressor Proteins / genetics
Repressor Proteins / metabolism*

Substances

Antigens, CD34
Core Binding Factor Alpha 2 Subunit
GFI1B protein, human
Proto-Oncogene Proteins
RUNX1 protein, human
Repressor Proteins

Associated data

PIR/187900
PIR/601399