High Serum Adipocyte Fatty Acid Binding Protein Is Associated with Metabolic Syndrome in Patients with Type 2 Diabetes

J Diabetes Res. 2016:2016:8380279. doi: 10.1155/2016/8380279. Epub 2016 Nov 29.

Abstract

Adipocyte fatty acid binding protein (A-FABP) is a key mediator of obesity-related metabolic syndrome (MetS). The aim of this study was to evaluate the relationship between A-FABP concentration and MetS in type 2 diabetes mellitus (DM) patients. Fasting blood samples were obtained from 165 type 2 DM volunteers. MetS and its components were defined using diagnostic criteria from the International Diabetes Federation. Among 165 DM patients, 113 patients (68.5%) had MetS. Diabetic persons who had MetS had significantly higher A-FABP levels (P < 0.001) than those without MetS. Female DM persons had higher A-FABP level than man (P < 0.001). No statistically significant differences in A-FABP levels were found in use of statin, fibrate, or antidiabetic drugs. Multivariate forward stepwise linear regression analysis revealed that body fat mass (P < 0.001), logarithmically transformed creatinine (log-creatinine; P < 0.001), female DM patients (P < 0.001), and logarithmically transformed high sensitive C-reactive protein (log-hs-CRP; P = 0.013) were positively correlated, while albumin (P = 0.004) and glomerular filtration rate (GFR; P = 0.043) were negatively correlated with serum A-FABP levels in type 2 DM patients. In this study, higher serum A-FABP level was positively associated with MetS in type 2 DM patients.

MeSH terms

  • Aged
  • Albumins / metabolism
  • Anthropometry
  • C-Reactive Protein / metabolism
  • Creatinine / metabolism
  • Diabetes Mellitus, Type 2 / blood*
  • Diabetes Mellitus, Type 2 / complications
  • Fatty Acid-Binding Proteins / metabolism*
  • Female
  • Glomerular Filtration Rate
  • Humans
  • Male
  • Metabolic Syndrome / blood*
  • Metabolic Syndrome / complications
  • Middle Aged
  • Multivariate Analysis
  • Obesity / blood*
  • Obesity / complications
  • Sex Factors

Substances

  • Albumins
  • FABP4 protein, human
  • Fatty Acid-Binding Proteins
  • C-Reactive Protein
  • Creatinine