The rs4285184 polymorphism of the MGAT1 gene as a risk factor for obesity in the Mexican population

Med Clin (Barc). 2017 Feb 23;148(4):149-152. doi: 10.1016/j.medcli.2016.07.037. Epub 2016 Nov 18.
[Article in English, Spanish]

Abstract

Background and objective: Obesity is a factor that contributes to the morbidity of certain diseases and to worldwide mortality. MGAT1 is a glycosyltransferase involved in the synthesis of protein-bound and lipid-bound oligosaccharides and its polymorphisms are possibly involved in the etiology of obesity. We investigated the association of the rs4285184 polymorphism of the MGAT1 gene with obesity in adults in the State of Colima, Mexico.

Methods: A case-control study was conducted that included 244 subjects. All of them were grouped according to their percentage of body fat, determined through bioelectrical impedance, and they were genotyped for the rs4285184 polymorphism of the MGAT1 gene through PCR-RFLP. The results were analyzed for their association with the percentage of body fat.

Results: The G allele had a frequency of 49.19 and 38.75% for the cases and controls, respectively (P=.020) (OR 1.53; 95% CI 1.068-2.193). The frequency of the A/G+G/G genotype was 75% in the obese patients, which was significantly higher compared with the 57.5% of the control group (P=.004) (OR 2.217; 95% CI 1.287-3.821).

Conclusions: The presence of the rs4285184 polymorphism of the MGAT1 gene increased the risk for developing body fat associated with obesity in the Mexican population.

Keywords: Asociación; Association; Gen; Gene; Obesidad; Obesity; Polimorfismo; Polymorphism.

MeSH terms

  • Adolescent
  • Adult
  • Amplified Fragment Length Polymorphism Analysis
  • Case-Control Studies
  • Female
  • Genetic Markers
  • Humans
  • Male
  • Mexico
  • Middle Aged
  • N-Acetylglucosaminyltransferases / genetics*
  • Obesity / genetics*
  • Polymorphism, Single Nucleotide*
  • Risk Factors
  • Young Adult

Substances

  • Genetic Markers
  • MGAT1 protein, human
  • N-Acetylglucosaminyltransferases