E3 ubiquitin ligase Cbl-b activates the p53 pathway by targeting Siva1, a negative regulator of ARF, in FLT3 inhibitor-resistant acute myeloid leukemia

Leukemia. 2017 Feb;31(2):502-505. doi: 10.1038/leu.2016.293. Epub 2016 Oct 24.

Authors

I-K Park^{1

2}, W Blum³, S D Baker^{1

2}, M A Caligiuri^{1

3}

Affiliations

¹ Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.
² Division of Pharmaceutics, College of Pharmacy, The Ohio State University, Columbus, OH, USA.
³ Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA.

No abstract available

Publication types

Letter
Research Support, N.I.H., Extramural

MeSH terms

Apoptosis Regulatory Proteins / antagonists & inhibitors*
Drug Resistance, Neoplasm*
Humans
Leukemia, Myeloid, Acute / metabolism*
Proto-Oncogene Proteins c-cbl / physiology*
Signal Transduction
Tumor Suppressor Protein p53 / metabolism
Ubiquitin-Protein Ligases / physiology
fms-Like Tyrosine Kinase 3 / antagonists & inhibitors

Substances

Apoptosis Regulatory Proteins
SIVA1 protein, human
Tumor Suppressor Protein p53
Proto-Oncogene Proteins c-cbl
Ubiquitin-Protein Ligases
fms-Like Tyrosine Kinase 3

Grants and funding