p62 in Cancer: Signaling Adaptor Beyond Autophagy

Cell. 2016 Oct 20;167(3):606-609. doi: 10.1016/j.cell.2016.09.030.

Abstract

Adaptor proteins participate in selective autophagy, which is critical for cellular detoxification and stress relief. However, new evidence supports an autophagy-independent key role of the adaptor p62 (encoded by the gene Sqstm1) in signaling functions central to tumor initiation in the epithelium and suppression of tumor progression in the stroma.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Autophagy*
  • Carcinogenesis / metabolism
  • Carcinogenesis / pathology*
  • Epithelial Cells / metabolism
  • Epithelial Cells / pathology
  • Humans
  • Neoplasms / metabolism
  • Neoplasms / pathology*
  • Sequestosome-1 Protein / metabolism*
  • Signal Transduction
  • Stress, Physiological
  • Tumor Microenvironment*

Substances

  • SQSTM1 protein, human
  • Sequestosome-1 Protein