Effects of GABA on the expression of type I collagen gene in normal human dermal fibroblasts

Biosci Biotechnol Biochem. 2017 Feb;81(2):376-379. doi: 10.1080/09168451.2016.1238296. Epub 2016 Oct 3.

Abstract

We examined the effects of GABA on type I collagen gene expression in normal human dermal fibroblasts. Real-time PCR analysis indicated GABA increased the level of type I collagen transcripts, and suppressed the expression of matrix metalloproteinase-1, which is a collagen-degrading enzyme. These results suggest GABA improves the skin elasticity by regulating type I collagen expression.

Keywords: GABA; MMP-1; collagen; normal human dermal fibroblasts.

MeSH terms

  • Collagen Type I / genetics*
  • Collagen Type I, alpha 1 Chain
  • Fibroblasts / drug effects*
  • Fibroblasts / metabolism*
  • Gene Expression Regulation / drug effects*
  • Humans
  • Matrix Metalloproteinase 1 / genetics
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism
  • Skin / cytology*
  • gamma-Aminobutyric Acid / pharmacology*

Substances

  • Collagen Type I
  • Collagen Type I, alpha 1 Chain
  • RNA, Messenger
  • gamma-Aminobutyric Acid
  • Matrix Metalloproteinase 1