Abstract
The male abnormal gene family contains 3 members, named mab21l1, mab21l2 and mab21l3. Since their first discovery in C. elegans, homologues of mab21l1 and mab21l2 have been found in Drosophila, Zebrafish, Xenopus, chicken, mouse and human. A number of studies have revealed that mab21 gene family members, mab21l1 and mab21l2, play important roles in regulating eye development. Here, we review the functions of the mab genes in regulating ocular development.
Publication types
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Review
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Eye / growth & development*
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Eye / metabolism
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Eye Proteins / physiology*
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Gene Expression
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Gene Expression Regulation, Developmental
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Homeodomain Proteins / physiology*
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Humans
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Intracellular Signaling Peptides and Proteins / physiology*
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Organ Specificity
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Signal Transduction
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Transforming Growth Factor beta / physiology
Substances
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Eye Proteins
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Homeodomain Proteins
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Intracellular Signaling Peptides and Proteins
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MAB21L1 protein, human
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MAB21L2 protein, human
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Transforming Growth Factor beta