Cutaneous hidradenoma: a study of 21 neoplasms revealing neither correlation between the cellular composition and CRTC1-MAML2 fusions nor presence of CRTC3-MAML2 fusions

Ann Diagn Pathol. 2016 Aug:23:8-13. doi: 10.1016/j.anndiagpath.2016.04.006. Epub 2016 Apr 16.

Abstract

Twenty-one hidradenomas from 20 patients (13 female, 7 male) ranging in age from 18 to 87years (mean, 57.75years; median, 60years) were studied for CRTC1-MAML2 and CRTC3-MAML2 fusions to find out whether there is a correlation between the particular cell type (polyhedral eosinophilic, clear, mucinous, epidermoid, and oncocytic) and presence the above alterations. CRTC1-MAML2 fusions were detected in 10 of the 21 neoplasms (47.6%). Fluorescence in situ hybridization for MAML2 break apart was analyzable in 13 specimens and in all these specimens was positive, including 4 tumors with no demonstrable CRTC1-MAML2 fusion. In none of the cases was a CRTC3-MAML2 fusion detected. No obvious correlation between the cellular composition and presence of t(11,19) translocation was found.

Keywords: Cutaneous adnexal tumors; Hidradenoma; MAML2; MECT1; Mucoepidermoid carcinoma.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Carcinoma, Mucoepidermoid / genetics*
  • Carcinoma, Mucoepidermoid / metabolism*
  • Carcinoma, Mucoepidermoid / pathology
  • DNA-Binding Proteins / genetics*
  • Female
  • Humans
  • In Situ Hybridization, Fluorescence / methods
  • Male
  • Middle Aged
  • Nuclear Proteins / genetics*
  • Oncogene Proteins, Fusion / genetics
  • Skin Neoplasms / genetics*
  • Skin Neoplasms / metabolism*
  • Skin Neoplasms / pathology
  • Trans-Activators
  • Transcription Factors / genetics*
  • Translocation, Genetic
  • Young Adult

Substances

  • CRTC1 protein, human
  • CRTC3 protein, human
  • DNA-Binding Proteins
  • MAML2 protein, human
  • Nuclear Proteins
  • Oncogene Proteins, Fusion
  • Trans-Activators
  • Transcription Factors