Serum amyloid A regulates monopoiesis in hyperlipidemic Ldlr(-/-) mice

FEBS Lett. 2016 Aug;590(16):2650-60. doi: 10.1002/1873-3468.12269. Epub 2016 Jul 8.

Abstract

We previously showed that feeding a Western-type diet (WTD) to Ldlr(-/-) mice lacking serum amyloid A (SAA) (Saa(-/-) Ldlr(-/-) mice), the level of total blood monocytes was higher than in Ldlr(-/-) mice. In this investigation we demonstrate that higher levels of bone marrow monocytes and macrophage-dendritic cell progenitor (MDP) cells were found in WTD-fed Saa(-/-) Ldlr(-/-) mice compared to Ldlr(-/-) mice and lower levels of GMP cells and CMP cells in Ldlr(-/-) mice. These data indicate that SAA regulates the level of bone marrow monocytes and their myeloid progenitors in hyperlipidemic Ldlr(-/-) mice.

Keywords: Western-type diet; monocytes; monopoiesis; serum amyloid A; stem cells.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Atherosclerosis / blood
  • Atherosclerosis / genetics
  • Bone Marrow / metabolism
  • Bone Marrow Transplantation
  • Dendritic Cells / metabolism
  • Disease Models, Animal
  • Humans
  • Hyperlipoproteinemias / blood
  • Hyperlipoproteinemias / genetics*
  • Hyperlipoproteinemias / pathology
  • Macrophages / metabolism
  • Mice
  • Mice, Knockout
  • Monocytes / metabolism
  • Monocytes / pathology
  • Myeloid Cells / metabolism
  • Receptors, LDL / genetics*
  • Serum Amyloid A Protein / genetics
  • Serum Amyloid A Protein / metabolism*

Substances

  • Receptors, LDL
  • Serum Amyloid A Protein