Abstract
Human T-cell leukemia virus type 1 (HTLV-1) can cause an aggressive malignancy known as adult T-cell leukemia/lymphoma (ATLL). The Tax protein encoded by the pX region of the HTLV-1 genome appears to be a key element in the early stage of ATLL development. In this study, we examined the expression of the downstream of tyrosine kinase (DOK) family members DOK1, DOK2 and DOK3, recently reported to be tumor suppressors, in HTLV-1-transformed T cells (MT-2 and HUT-102) and TL-Om1 cells derived from ATLL leukemic cells. DOK2 and DOK3 expression was significantly reduced in MT-2, HUT-102, and TL-Om1 cells compared with their expression in uninfected T cells, and the expression of DOK3 was reduced by the induction of Tax expression in T cells.
Keywords:
adult T-cell leukemia/lymphoma; downstream of tyrosine kinase 1; DOK1; DOK2; DOK3; human T-cell leukemia virus type; tax..
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adaptor Proteins, Signal Transducing / genetics*
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Adaptor Proteins, Signal Transducing / metabolism
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Adult
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DNA-Binding Proteins / genetics*
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DNA-Binding Proteins / metabolism
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Gene Products, tax / genetics
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Gene Products, tax / metabolism
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Human T-lymphotropic virus 1 / genetics
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Human T-lymphotropic virus 1 / physiology*
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Humans
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Leukemia-Lymphoma, Adult T-Cell / genetics*
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Leukemia-Lymphoma, Adult T-Cell / metabolism
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Leukemia-Lymphoma, Adult T-Cell / virology
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Phosphoproteins / genetics*
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Phosphoproteins / metabolism
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RNA-Binding Proteins / genetics*
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RNA-Binding Proteins / metabolism
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T-Lymphocytes / metabolism*
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T-Lymphocytes / virology
Substances
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Adaptor Proteins, Signal Transducing
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DNA-Binding Proteins
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DOK1 protein, human
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DOK2 protein, human
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DOK3 protein, human
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Gene Products, tax
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Phosphoproteins
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RNA-Binding Proteins
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tax protein, Human T-lymphotrophic virus 1