Elevated expression of RNA methyltransferase BCDIN3D predicts poor prognosis in breast cancer

Oncotarget. 2016 Aug 16;7(33):53895-53902. doi: 10.18632/oncotarget.9656.

Abstract

Background: BCDIN3D is a member of the Bin3 methyl-transferase family that targets the 5' mono-phosphate of nucleic acids. Although BCDIN3D has been shown to increase tumorigenic phenotypes and invasiveness in MDA-MB-231 cells, its the clinical implications in breast cancer remain unclear.

Methods: We screened for BCDIN3D using tissue microarrays constructed from 250 patients who were histologically confirmed to have invasive ductal breast carcinoma at the Fudan University Shanghai Cancer Center.

Results: The survival analysis by Kaplan-Meier and Cox regression showed that BCDIN3D expression level served as a prognostic factor for disease-free survival (P = 0.042). The prognostic value of BCDIN3D was most significant in triple-negative breast cancer (TNBC) patients (P = 0.007).

Conclusions: BCDIN3D might serve as an important prognostic factor for TNBC patients.

Keywords: BCDIN3D; TNBC; breast cancer.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Biomarkers, Tumor / analysis*
  • Breast Neoplasms / enzymology
  • Breast Neoplasms / metabolism
  • Breast Neoplasms / pathology
  • Carcinoma, Ductal, Breast / enzymology
  • Carcinoma, Ductal, Breast / metabolism
  • Carcinoma, Ductal, Breast / pathology*
  • Disease-Free Survival
  • Female
  • Humans
  • Kaplan-Meier Estimate
  • Methyltransferases / analysis
  • Methyltransferases / biosynthesis*
  • Middle Aged
  • Prognosis
  • Proportional Hazards Models
  • Triple Negative Breast Neoplasms / metabolism
  • Triple Negative Breast Neoplasms / mortality
  • Triple Negative Breast Neoplasms / pathology*

Substances

  • Biomarkers, Tumor
  • BCDIN3D protein, human
  • Methyltransferases