Platelet clearance by the hepatic Ashwell-Morrell receptor: mechanisms and biological significance

Karin M Hoffmeister; Hervé Falet

doi:10.1016/S0049-3848(16)30370-X

Platelet clearance by the hepatic Ashwell-Morrell receptor: mechanisms and biological significance

Thromb Res. 2016 May;141 Suppl 2(Suppl 2):S68-72. doi: 10.1016/S0049-3848(16)30370-X.

Authors

Karin M Hoffmeister¹, Hervé Falet²

Affiliations

¹ Division of Hematology, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115. Electronic address: khoffmeister@bwh.harvard.edu.
² Division of Hematology, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115.

Abstract

The daily production of billions of platelets must be regulated to avoid spontaneous bleeding or arterial occlusion and organ damage. Complex mechanisms control platelet production and clearance in physiological and pathological conditions. This review will focus on the mechanisms of platelet senescence with specific emphasis on the role of post-translational modifications in platelet life-span and thrombopoietin production downstream of the hepatic Ashwell-Morrell receptor.

Keywords: Ashwell Morell Receptor; JAK2; STAT3; glycans; platelet clearance; thrombopoietin.

Publication types

Review

MeSH terms

Animals
Asialoglycoprotein Receptor / metabolism*
Blood Platelets / cytology*
Blood Platelets / metabolism
Blood Platelets / pathology
Cellular Senescence*
Humans
Protein Processing, Post-Translational
Receptors, Interleukin-6 / metabolism
Signal Transduction
Thrombopoietin / metabolism

Substances

Asialoglycoprotein Receptor
Receptors, Interleukin-6
Thrombopoietin

Abstract

Publication types

MeSH terms

Substances

Grants and funding