Novel aspects of platelet factor XIII function

Joanne L Mitchell; Nicola J Mutch

doi:10.1016/S0049-3848(16)30356-5

Novel aspects of platelet factor XIII function

Thromb Res. 2016 May:141 Suppl 2:S17-21. doi: 10.1016/S0049-3848(16)30356-5.

Authors

Joanne L Mitchell¹, Nicola J Mutch²

Affiliations

¹ Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK.
² Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK. Electronic address: n.j.mutch@abdn.ac.uk.

PMID: 27207415
DOI: 10.1016/S0049-3848(16)30356-5

Abstract

Pools of factor XIII (FXIII) exist in the plasma and within the cytoplasm of hematopoietic cells, including platelets. The functions of the cellular form, FXIII-A, have been assumed to be intracellular in nature, as the protein lacks a signal sequence for its release. Mounting evidence now suggests that platelet FXIII-A modulates hemostasis by several different mechanisms. In this condensed review we discuss recent advances in our understanding of the novel intracellular and extracellular functions of platelet FXIII-A.

Keywords: factor XIII; fibrin; fibrinolysis; platelets; α(2)-antiplasmin.

Publication types

Review

MeSH terms

Animals
Blood Platelets / cytology
Blood Platelets / metabolism*
Factor XIII / metabolism*
Fibrin / metabolism
Fibrinolysis
Humans
Platelet Activation
alpha-2-Antiplasmin / metabolism

Substances

alpha-2-Antiplasmin
Fibrin
Factor XIII

Abstract

Publication types

MeSH terms

Substances

Grants and funding