The level of the Phf10 protein, a PBAF chromatin-remodeling complex subunit, correlates with the Mts1/S100A4 expression in human cancer cell lines

N V Soshnikova; Yu P Simonov; A V Brechalov; T N Portseva; E V Pankratova; S G Georgieva

doi:10.1134/S1607672916020228

The level of the Phf10 protein, a PBAF chromatin-remodeling complex subunit, correlates with the Mts1/S100A4 expression in human cancer cell lines

Dokl Biochem Biophys. 2016 Mar;467(1):162-4. doi: 10.1134/S1607672916020228. Epub 2016 May 20.

Authors

N V Soshnikova¹, Yu P Simonov², A V Brechalov², T N Portseva², E V Pankratova², S G Georgieva²

Affiliations

¹ Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, ul. Vavilova 32, Moscow, 119991, Russia. so2615nat@gmail.com.
² Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, ul. Vavilova 32, Moscow, 119991, Russia.

PMID: 27193724
DOI: 10.1134/S1607672916020228

Abstract

Mts1 (S100A4) protein is a marker of metastatic tumor cells, which is associated with a poor diagnostic prognosis for cancer progression. Therefore, it is important to study the S100A4 gene expression. According to our preliminary data, PHF10, a PBAF remodeling complex component, can play an important role in the transcription regulation of the S100A4 gene. We studied the expression of S100A4 and the total PHF10 protein in some cell lines. We have found that, in the cell lines studied, the PHF10 expression is correlated with the S100A4 expression.

MeSH terms

Blotting, Western
Cell Line, Tumor
Gene Expression Regulation, Neoplastic*
Homeodomain Proteins / metabolism*
Humans
Neoplasm Proteins / metabolism*
Neoplasms / metabolism*
Polymerase Chain Reaction
Protein Isoforms
RNA, Messenger / metabolism
S100 Calcium-Binding Protein A4 / metabolism*
Transcription, Genetic / physiology

Substances

Homeodomain Proteins
Neoplasm Proteins
PHF10 protein, human
Protein Isoforms
RNA, Messenger
S100 Calcium-Binding Protein A4
S100A4 protein, human