Abstract
The family of JADE proteins includes three paralogues encoded by individual genes and designated PHF17 (JADE1), PHF16 (JADE2), and PHF15 (JADE3). All three JADE proteins bear in tandem two Plant Homeo-domains (PHD) which are zinc finger domains. This review focuses on one member of the JADE family, JADE1. Studies addressing the biochemical, cellular and biological role of JADE1 are discussed. Recent discoveries of JADE1 function in the regulation of the epithelial cell cycle with potential relevance to disease are presented. Unresolved questions and future directions are formulated.
Copyright © 2016 Elsevier B.V. All rights reserved.
MeSH terms
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Acute Kidney Injury / genetics*
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Acute Kidney Injury / metabolism
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Acute Kidney Injury / pathology
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Amino Acid Sequence
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Animals
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Cell Cycle / genetics
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Chromosomes, Human, Pair 4 / chemistry
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Epithelial Cells / cytology
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Epithelial Cells / metabolism*
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Gene Expression Regulation*
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Homeodomain Proteins / chemistry
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Homeodomain Proteins / genetics*
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Homeodomain Proteins / metabolism
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Humans
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Mice
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Neoplasms / genetics*
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Neoplasms / metabolism
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Neoplasms / pathology
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Protein Isoforms / chemistry
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Protein Isoforms / genetics
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Protein Isoforms / metabolism
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Regeneration / genetics*
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Sequence Alignment
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Sequence Homology, Amino Acid
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Signal Transduction
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Tumor Suppressor Proteins / chemistry
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Tumor Suppressor Proteins / genetics*
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Tumor Suppressor Proteins / metabolism
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Von Hippel-Lindau Tumor Suppressor Protein / genetics
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Von Hippel-Lindau Tumor Suppressor Protein / metabolism
Substances
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Homeodomain Proteins
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JADE1 protein, human
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Protein Isoforms
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Tumor Suppressor Proteins
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Von Hippel-Lindau Tumor Suppressor Protein
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VHL protein, human