Multifunctional protein: cardiac ankyrin repeat protein

Na Zhang; Xiao-Jie Xie; Jian-An Wang

doi:10.1631/jzus.B1500247

Multifunctional protein: cardiac ankyrin repeat protein

J Zhejiang Univ Sci B. 2016 May;17(5):333-41. doi: 10.1631/jzus.B1500247.

Authors

Na Zhang¹, Xiao-Jie Xie¹, Jian-An Wang¹

Affiliation

¹ Cardiovascular Key Lab of Zhejiang Province, Department of Cardiology, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China.

Abstract

Cardiac ankyrin repeat protein (CARP) not only serves as an important component of muscle sarcomere in the cytoplasm, but also acts as a transcription co-factor in the nucleus. Previous studies have demonstrated that CARP is up-regulated in some cardiovascular disorders and muscle diseases; however, its role in these diseases remains controversial now. In this review, we will discuss the continued progress in the research related to CARP, including its discovery, structure, and the role it plays in cardiac development and heart diseases.

Keywords: Cardiac ankyrin repeat protein (CARP); Cardiac development; Cardiovascular disease.

Publication types

Review

MeSH terms

Animals
Ankyrin Repeat
Apoptosis
Atherosclerosis / genetics
Cardiomegaly / genetics
Cardiomyopathy, Dilated / genetics
Cytoplasm / metabolism
Doxorubicin / adverse effects
Gene Expression Regulation*
Heart / embryology*
Heart / growth & development*
Heart Failure / genetics
Humans
Mice
Muscle Proteins / chemistry
Muscle Proteins / genetics*
Muscle Proteins / physiology*
Myocardial Ischemia / genetics
Myocardium / metabolism
Nuclear Proteins / chemistry
Nuclear Proteins / genetics*
Nuclear Proteins / physiology*
Repressor Proteins / chemistry
Repressor Proteins / genetics*
Repressor Proteins / physiology*

Substances

ANKRD1 protein, human
Ankrd1 protein, mouse
Muscle Proteins
Nuclear Proteins
Repressor Proteins
Doxorubicin