Methionine synthase 2756AA polymorphism is associated with the risk of cognitive impairment in patients with late-life depression

Ya-Hsu Yang; Chih-Chiang Chiu; Hao-Wei Teng; Chih-Pang Chu; Ching-Jui Chang; Wei-Che Chiu; Chin-Hsin Chen; Mong-Liang Lu; Shen-Ing Liu; Shih-Yi Huang; Hsing-Cheng Liu; I-Wen Sun

doi:10.1111/appy.12242

Methionine synthase 2756AA polymorphism is associated with the risk of cognitive impairment in patients with late-life depression

Asia Pac Psychiatry. 2017 Mar;9(1). doi: 10.1111/appy.12242. Epub 2016 Apr 25.

Authors

Ya-Hsu Yang^{1

2}, Chih-Chiang Chiu^{3

4}, Hao-Wei Teng^{2

5}, Chih-Pang Chu³, Ching-Jui Chang⁶, Wei-Che Chiu⁶, Chin-Hsin Chen^{4

7}, Mong-Liang Lu^{4

7}, Shen-Ing Liu⁸, Shih-Yi Huang⁹, Hsing-Cheng Liu^{3

4}, I-Wen Sun⁸

Affiliations

¹ Department of Psychiatry, Taipei City Hospital, Zen-A Branch, Taipei, Taiwan.
² School of Medicine, National Yang-Ming University, Taipei, Taiwan.
³ Department of Psychiatry, Taipei City Psychiatric Center, Taipei City Hospital, Taipei, Taiwan.
⁴ Department of Psychiatry, School of Medicine, Taipei Medical University, Taipei, Taiwan.
⁵ Division of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
⁶ Department of Psychiatry, Cathay General Hospital, Taipei, Taiwan.
⁷ Department of Psychiatry, Taipei Medical University - Wan Fang Hospital, Taipei, Taiwan.
⁸ Department of Psychiatry, Mackay Memorial Hospital, Taipei, Taiwan.
⁹ Department of Nutrition, School of Nutrition and Health Science, Taipei Medical University, Taipei, Taiwan.

PMID: 27111719
DOI: 10.1111/appy.12242

Abstract

Backgrounds: Apolipoprotein E epsilon-4 (APOE ε4) allele, methylenetetrahydrofolate reductase (MTHFR C677T), and methionine synthase (MTR A2756G) were tested their associations with cognitive impairment in people with late-life depression (LLD).

Methods: People with LLD were assessed by mini-mental state examination and were examined the distribution of APOE ε4 allele, MTHFR, and MTR polymorphisms.

Results: Odds ratio of MTR 2756 AA to MTR 2756 AG and GG genotypes for the risk of cognitive impairment was 5.80 (95% confidence interval = 1.18-28.50; P = 0.03).

Conclusion: People with LLD carrying MTR2756 AA genotype have higher risk of cognitive impairment than those carrying G allele.

MeSH terms

5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase / genetics*
Aged
Alleles
Apolipoproteins E / genetics
Cognitive Dysfunction / complications
Cognitive Dysfunction / genetics*
Depressive Disorder / complications
Depressive Disorder / genetics*
Female
Gene Frequency
Genetic Predisposition to Disease*
Genotype
Humans
Male
Methylenetetrahydrofolate Reductase (NADPH2) / genetics
Middle Aged
Polymorphism, Single Nucleotide*
Risk Factors

Substances

Apolipoproteins E
Methylenetetrahydrofolate Reductase (NADPH2)
5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase