Nuclear m(6)A Reader YTHDC1 Regulates mRNA Splicing

Ian A Roundtree; Chuan He

doi:10.1016/j.tig.2016.03.006

Nuclear m(6)A Reader YTHDC1 Regulates mRNA Splicing

Trends Genet. 2016 Jun;32(6):320-321. doi: 10.1016/j.tig.2016.03.006. Epub 2016 Apr 2.

Authors

Ian A Roundtree¹, Chuan He²

Affiliations

¹ Department of Biochemistry and Molecular Biology, Medical Scientist Training Program, The University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA.
² Department of Chemistry, Department of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics and Howard Hughes Medical Institute, The University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA. Electronic address: chuanhe@uchicago.edu.

PMID: 27050931
DOI: 10.1016/j.tig.2016.03.006

Abstract

N(6)-Methyladenosine (m(6)A) is emerging as a chemical mark that broadly affects the flow of genetic information in various biological processes in eukaryotes. Recently, Xiao et al. reported that the nuclear m(6)A reader protein YTHDC1 impacts mRNA splicing, providing a transcriptome-wide glance of splicing changes affected by this mRNA methylation reader protein.

Keywords: N(6)-methyladenosine; YTHDC1; mRNA splicing.

Published by Elsevier Ltd.

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MeSH terms

Adenosine / analogs & derivatives*
Adenosine / genetics
Eukaryota / genetics
Methylation
Nerve Tissue Proteins / genetics*
RNA Processing, Post-Transcriptional / genetics
RNA Splicing / genetics*
RNA Splicing Factors / genetics*
RNA, Messenger / genetics
Transcriptome / genetics

Substances

Nerve Tissue Proteins
RNA Splicing Factors
RNA, Messenger
YTHDC1 protein, human
N-methyladenosine
Adenosine