Abstract
The six transmembrane protein of prostate (STAMP) proteins, also known as six transmembrane epithelial antigen of prostate (STEAPs), comprises three members: STAMP1-3. Their expression is regulated by a variety of stimuli, including hormones and cytokines, in varied settings and tissues with important roles in secretion and cell differentiation. In addition, they are implicated in metabolic and inflammatory diseases and cancer. Here, we review the current knowledge on the role of STAMPs in both physiological and pathological states.
Keywords:
Inflammation; Ironreductase; Metabolism; Prostate cancer; STAMP; STEAP.
Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Cell Cycle Proteins
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Cell Differentiation
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Gene Expression Regulation
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Humans
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Inflammation / metabolism
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Membrane Proteins / chemistry
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Membrane Proteins / genetics
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Membrane Proteins / metabolism*
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Metabolic Diseases / metabolism
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Neoplasm Proteins / chemistry
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Neoplasm Proteins / genetics
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Neoplasm Proteins / metabolism*
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Neoplasms / metabolism
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Oncogene Proteins / chemistry
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Oncogene Proteins / genetics
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Oncogene Proteins / metabolism*
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Oxidoreductases / chemistry
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Oxidoreductases / genetics
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Oxidoreductases / metabolism*
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Tissue Distribution
Substances
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Cell Cycle Proteins
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Membrane Proteins
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Neoplasm Proteins
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Oncogene Proteins
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Oxidoreductases
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STEAP3 protein, human
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STEAP2 protein, human
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STEAP4 protein, human