Commensal cutaneous bacteria are believed to play a role in skin homeostasis, possibly by counteracting the effects of pathogenic inflammation. In this issue, Xia et al. show that Staphylococcus epidermidis is involved in the regulation of Propionibacterium acnes-induced inflammation. Staphylococcal lipoteichoic acid induces miR-143, which in turn inhibits toll-like receptor 2 mRNA to decrease toll-like receptor 2 protein and consequently suppresses P. acnes-induced proinflammatory cytokines.
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