The Expression of IL-21 Is Promoted by MEKK4 in Malignant T Cells and Associated with Increased Progression Risk in Cutaneous T-Cell Lymphoma

J Invest Dermatol. 2016 Apr;136(4):866-869. doi: 10.1016/j.jid.2015.12.033. Epub 2016 Jan 21.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Disease Progression
  • Gene Expression Regulation, Neoplastic*
  • Humans
  • Inflammation
  • Interleukins / genetics
  • Interleukins / metabolism*
  • Lymphoma, T-Cell / metabolism*
  • MAP Kinase Kinase Kinase 4 / metabolism*
  • MAP Kinase Signaling System
  • Phosphorylation
  • RNA, Small Interfering / metabolism
  • STAT3 Transcription Factor / metabolism
  • Signal Transduction
  • Skin Neoplasms / metabolism*
  • T-Lymphocytes / metabolism*

Substances

  • Interleukins
  • RNA, Small Interfering
  • STAT3 Transcription Factor
  • STAT3 protein, human
  • MAP Kinase Kinase Kinase 4
  • MAP3K4 protein, human
  • interleukin-21