Parameters determining the efficacy of CD32 to inhibit activation of FcεRI in human basophils

Donald MacGlashan Jr; Robert G Hamilton

doi:10.1016/j.jaci.2015.10.043

Parameters determining the efficacy of CD32 to inhibit activation of FcεRI in human basophils

J Allergy Clin Immunol. 2016 Apr;137(4):1256-1258.e11. doi: 10.1016/j.jaci.2015.10.043. Epub 2016 Jan 7.

Authors

Donald MacGlashan Jr¹, Robert G Hamilton²

Affiliations

¹ Department of Medicine, Johns Hopkins Asthma and Allergy Center, Baltimore, Md. Electronic address: dmacglas@jhmi.edu.
² Department of Medicine, Johns Hopkins Asthma and Allergy Center, Baltimore, Md.

Abstract

The conditions needed to readily observe the role of CD32 in modulating IgE-mediated secretion are enumerated and include consideration of IgG subclass, with a possible emphasis on IgG3, antibody:antigen ratios, but with no evidence that polymorphic variants of CD32 influence its function.

Publication types

Letter
Research Support, N.I.H., Extramural

MeSH terms

Basophils / immunology*
Humans
Immunoglobulin E / immunology*
Immunoglobulin G / immunology*
Receptors, IgE / antagonists & inhibitors*
Receptors, IgE / immunology
Receptors, IgG / immunology*

Substances

Immunoglobulin G
Receptors, IgE
Receptors, IgG
Immunoglobulin E

Abstract

Publication types

MeSH terms

Substances

Grants and funding