Primary phospholipase C and brain disorders

Yong Ryoul Yang; Du-Seock Kang; Cheol Lee; Heon Seok; Matilde Y Follo; Lucio Cocco; Pann-Ghill Suh

doi:10.1016/j.jbior.2015.11.003

Primary phospholipase C and brain disorders

Adv Biol Regul. 2016 May:61:80-5. doi: 10.1016/j.jbior.2015.11.003. Epub 2015 Nov 27.

Authors

Yong Ryoul Yang¹, Du-Seock Kang¹, Cheol Lee¹, Heon Seok², Matilde Y Follo³, Lucio Cocco³, Pann-Ghill Suh⁴

Affiliations

¹ Center for Cell to Cell Communication in Cancers (C5), School of Life Sciences, Ulsan National Institute of Science and Technology, Ulsan, 689-798, Republic of Korea.
² Department of Biomedical Engineering, Jungwon University, Goesan, Chungcheongbukdo, Republic of Korea.
³ Cellular Signaling Laboratory, Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
⁴ Center for Cell to Cell Communication in Cancers (C5), School of Life Sciences, Ulsan National Institute of Science and Technology, Ulsan, 689-798, Republic of Korea. Electronic address: pgsuh@unist.ac.kr.

PMID: 26639088
DOI: 10.1016/j.jbior.2015.11.003

Abstract

In the brain, the primary phospholipase C (PLC) proteins, PLCβ, and PLCγ, are activated primarily by neurotransmitters, neurotrophic factors, and hormones through G protein-coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs). Among the primary PLC isozymes, PLCβ1, PLCβ4, and PLCγ1 are highly expressed and differentially distributed, suggesting a specific role for each PLC subtype in different regions of the brain. Primary PLCs control neuronal activity, which is important for synapse function and development. In addition, dysregulation of primary PLC signaling is linked to several brain disorders including epilepsy, schizophrenia, bipolar disorder, Huntington's disease, depression and Alzheimer's disease. In this review, we included current knowledge regarding the roles of primary PLC isozymes in brain disorders.

Keywords: Brain disorder; PLCβ1; PLCβ4; PLCγ1; Phospholipase C.

Publication types

Review

MeSH terms

Alzheimer Disease / enzymology
Alzheimer Disease / genetics
Alzheimer Disease / pathology
Bipolar Disorder / enzymology
Bipolar Disorder / genetics
Bipolar Disorder / pathology
Brain / enzymology*
Brain / pathology
Depression / enzymology
Depression / genetics
Depression / pathology
Epilepsy / enzymology
Epilepsy / genetics
Epilepsy / pathology
Gene Expression Regulation
Humans
Huntington Disease / enzymology
Huntington Disease / genetics
Huntington Disease / pathology
Nerve Growth Factors / genetics
Nerve Growth Factors / metabolism
Neurotransmitter Agents / metabolism
Phospholipase C beta / genetics*
Phospholipase C beta / metabolism
Phospholipase C gamma / genetics*
Phospholipase C gamma / metabolism
Receptors, G-Protein-Coupled / genetics
Receptors, G-Protein-Coupled / metabolism
Schizophrenia / enzymology
Schizophrenia / genetics
Schizophrenia / pathology
Signal Transduction*

Substances

Nerve Growth Factors
Neurotransmitter Agents
Receptors, G-Protein-Coupled
PLCB1 protein, human
PLCB4 protein, human
PLCG1 protein, human
Phospholipase C beta
Phospholipase C gamma