B cells assume the command

Sci Transl Med. 2015 Oct 21;7(310):310fs42. doi: 10.1126/scitranslmed.aad2740.

Authors

Ari Waisman¹, Thomas Korn²

Affiliations

¹ Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg-University of Mainz, 55131 Mainz, Germany. waisman@uni-mainz.de.
² Department of Neurology, Klinikum rechts der Isar, Technische Universitaet Muenchen, 81675 Munich, Germany. Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.

PMID: 26491075
DOI: 10.1126/scitranslmed.aad2740

Abstract

A proinflammatory B cell cytokine activates autoimmunity, and B cell depletion treats multiple sclerosis (Li et al., this issue).

Copyright © 2015, American Association for the Advancement of Science.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

B-Lymphocytes / metabolism*
Granulocyte-Macrophage Colony-Stimulating Factor / biosynthesis*
Humans
Inflammation Mediators / metabolism*
Lymphocyte Depletion*
Multiple Sclerosis / pathology*

Substances

Inflammation Mediators
Granulocyte-Macrophage Colony-Stimulating Factor